While flu and RSV infections were uncommon in 2020 and 2021, a dramatic increase in infections was documented in the fall and early winter of 2022. We have therefore adapted I-PREVENT to include prevention against flu and RSV. It should be noted that the medications in I-PREVENT are inexpensive, safe, and widely available.
This protocol includes a section on how to prevent infection before you’ve been exposed (pre-exposure/long term) as well as how to prevent infection if you have potentially been exposed (post-exposure/acute, short-term).
At the onset of flu-like symptoms please refer to the I-CARE: Early COVID Treatment or I-CARE: RSV and Flu Treatment Protocols.
Learn about nutritional therapeutics and how they can help with COVID-19.
Read about the safety of vitamins and nutraceuticals in pregnancy.
How to prevent infection before you’ve been exposed
Table 1. Guidance on Upfront Loading Dose Regimens to Replenish Vitamin D Stores in the Body
When serum vitamin D levels are available, the doses provided in this table can be used for the longer-term maintenance of serum 25(OH)D concentration above 50 ng/mL (125 nmol/L). The table provides the initial bolus dose, weekly dose, frequency, and the duration of administration of oral vitamin D in non-emergency situations, in a non-obese, 70 kg adult. *
BASELINE VITAMIN D (NG/ML)** |
VITAMIN D DOSE, 50,000 IU CAPSULES: INITIAL AND WEEKLY $ |
DURATION (NUMBER OF WEEKS) |
TOTAL AMOUNT NEEDED TO CORRECT VIT. D, DEFICIENCY (IU, IN MILLIONS)# |
|
---|---|---|---|---|
INITIAL BOLUS DOSE (IU) | FOLLOW-UP: $$ THE NUMBER OF 50,000 IU CAPS/WEEK |
|||
< 10 | 300,000 | x 3 | 8 to 10 | 1.5 to 1.8 |
11-15 | 200,000 | x 2 | 8 to 10 | 1.0 to 1.2 |
16-20 | 200,000 | x 2 | 6 to 8 | 0.8 to 1.0 |
21-30 | 100,000 | x 2 | 4 to 6 | 0.5 to 0.7 |
31-40 | 100,000 | x 2 | 2 to 4 | 0.3 to 0.5 |
41-50 | 100,000 | x 1 | 2 to 4 | 0.2 to 0.3 |
* A suitable daily or weekly maintenance dose to be started after completing the loading-dose schedule. The dose should be adjusted for those who are overweight (higher) or underweight (lower).
** To convert ng/mL to nmol/L, multiply the amount in ng by 2.5; One µg = 40 IU.
$ Mentioned replacement doses can be taken as single, cumulative doses, two to three times a week spread out over a few weeks.
$$ From the day one of week two onwards.
# Estimated total Vitamin D dose needed to replenish the body stores (i.e., the deficit) is provided in the last column.
(Table adapted with permission from S.J. Wimalawansa)
Table 2. Vitamin D Dosing in the Absence of a Baseline Vitamin D Level
Longer-term maintenance schedules of oral vitamin D based on body weight to maintain the levels above 50 ng/mL (125 nmol/L) when the serum 25(OH)D concentrations are unknown.
BODYWEIGHT CATEGORY | DOSE KG/DAY (IU) |
DOSE (IU) (DAILY OR WEEKLY)* |
||
---|---|---|---|---|
(AGE) OR USING BMI (FOR AGE > 18) (KG/HT. M2) |
AVERAGE BODY WEIGHT (KG) |
DAILY DOSE (IU) |
ONCE A WEEK (IU) |
|
(Age 1-5) | 5-13 | 70 | 350-900 | 3000-5000 |
(Age 6-12) | 14-40 | 70 | 1000-2800 | 7000-28,000 |
(Age 13-18) | 40-50 | 70 | 2800-3500 | 20,000-25,000 |
BMI ≤ 19 | 50-60 (under-weight adult) |
60 to 80 | 3500-5000 | 25,000-35,000 |
BMI < 29 | 70-90 (normal; non-obese) |
70 to 90 | 5000-8000 | 35,000-50,000 |
BMI 30-39 | 90-120 (obese persons)# |
90 to 130 | 8000-15,000 | 50,000-100,000 |
BMI ≥ 40$ | 140 (morbidly obese)$ |
140 to 180 | 18,000-30,000 | 125,000-200,000 |
* Example of a daily or once-a-week dose range for adults with specific body types (based on BMI for white Caucasians and body weight for other ethnic groups). Appropriate dose reductions are necessary for children.
# For those with chronic comorbid conditions, such as hypertension, diabetes, asthma, COPD, CKD, depression, and osteoporosis, and to reduce all-cause mortality, higher doses of vitamin D are needed. For them, one can use the doses that are recommended for persons with obesity (BMI, 30–39: the third row).
$ Those with multiple sclerosis, cancer, migraine headaches, and psoriasis, and those routinely taking medications such as anti-epileptic and anti-retroviral agents that significantly increase the catabolism of vitamin D should consider taking age-appropriate doses recommended for those with morbid obesity (BMI ≥ 40; the higher end of the daily doses in the fourth row).
(Table adapted with permission from S.J. Wimalawansa)
How to prevent infection if you have potentially been exposed
Table 3. How to calculate ivermectin dose
Note that ivermectin is available in different strengths (e.g., 3, 6 or 12 mg) and administration forms (tablets, capsules, drops, etc.). Note that tablets can be halved for more accurate dosing, while capsules cannot.
HOW MUCH DO I WEIGH? | WHAT DOSE DOES THE PROTOCOL SAY? | ||||
---|---|---|---|---|---|
IN POUNDS | IN KILOGRAMS | 0.2 MG/KG: | 0.3 MG/KG: | 0.4 MG/KG: | 0.6 MG/KG: |
70-90 | 32-41 | 6-8 mg | 10-12 mg | 13-16 mg | 19-25 mg |
91-110 | 41-50 | 8-10 mg | 12-15 mg | 17-20 mg | 25-30 mg |
111-130 | 50-59 | 10-12 mg | 15-18 mg | 20-24 mg | 30-35 mg |
131-150 | 60-68 | 12-14 mg | 18-20 mg | 24-27 mg | 36-41 mg |
151-170 | 69-77 | 14-15 mg | 21-23 mg | 27-31 mg | 41-46 mg |
171-190 | 78-86 | 16-17 mg | 23-26 mg | 31-35 mg | 47-52 mg |
191-210 | 87-95 | 17-19 mg | 26-29 mg | 35-38 mg | 52-57 mg |
211-230 | 96-105 | 19-21 mg | 29-31 mg | 38-42 mg | 58-63 mg |
231-250 | 105-114 | 21-23 mg | 32-34 mg | 42-45 mg | 63-68 mg |
251-270 | 114-123 | 23-25 mg | 34-37 mg | 46-49 mg | 68-74 mg |
271-290 | 123-132 | 25-26 mg | 37-40 mg | 49-53 mg | 74-79 mg |
291-310 | 132-141 | 26-28 mg | 40-42 mg | 53-56 mg | 79-85 mg |
This protocol is solely for educational purposes regarding potentially beneficial therapies for COVID-19. Never disregard professional medical advice because of something you have read on our website and releases. This protocol is not intended to be a substitute for professional medical advice, diagnosis, or treatment with regard to any patient. Treatment for an individual patient should rely on the judgement of a physician or other qualified health provider. Always seek their advice with any questions you may have regarding your health or medical condition. Please note our full disclaimer at: www.flccc.net/disclaimer
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https://covid19criticalcare.com/protocol/i-prevent-covid-flu-rsv/